A Study of Predicting the Severity Following Glufosinate Ammonium Containing Herbicide Poisoning Experienced in Single Emergency Medical Institution

PURPOSE: Owing to the increased agricultural use of the herbicide glufosinate ammonium (GLA), the incidence of GLA poisoning has recently increased. Therefore, we investigated the possible predictive factors associated with severe complications following GLA poisoning. METHODS: A retrospective analysis of medical records was conducted based on 76 patients who had visited our regional emergency medical center with GLA poisoning from 2006 to 2017. Severe complications were defined as respiratory failure requiring intubation, systolic blood pressure less than 90 mmHg, Glasgow Coma Scale (GCS) less than 8, and presence of seizure. RESULTS: Age, ingested amount and ingested amount per weight were significantly greater in the severe group (p<0.001). PSS grade 2 or higher was more common in the severe group (p<0.001), and In addition, the APACHE II score was significantly higher in the severe group (p<0.001), as were the SOFA scores (p=0.002). Serum ammonia levels were significantly higher in the severe group (p=0.007), while MDRD-GFR was smaller in the severe group (p=0.002). The spot urine protein levels were significantly higher in the severe group (p=0.005), as was the urine protein to creatinine ratio (p=0.001). Upon multivariate analysis, the amount ingested per weight and PSS grade 2 or higher were identified as significant predictors. CONCLUSION: Our study showed that MDRD-GFR was significantly lower in the severe group after GLA poisoning. PSS grade 2 or higher and ingested amount per weight may be useful to evaluate the severity of complications after GLA poisoning.

A Study on the Optimal Culture Condition and Biomechanical Properties of In Vitro Tissue Engineered Cartilage Using a Fibrin Glue Scaffold

The purpose of this study was to examine the feasibility of using fibrin glue polymer designed to produce tissue-engineered cartilage by in vitro culture and to determine the optimal fibrinogen and chondrocyte concentrations required to generate cartilage and to evaluate the biomechanical properties of the generated cartilages. The most favorable fibrinogen and chondrocyte concentrations were determined by measuring the volume and weight gains, evaluating the histologic changes and measuring the biomechanical properties after construction of 12 different chondrocyte-fibrin glue constructs. The results are as follows. 1. The fibrin glues without chondrocytes degraded during 8 weeks of culture period. 2. The construct gains more weight in those with higher chondrocyte and fibrinogen concentration. 3. Histologic analysis of the generated cartilage showed nearly homogeneous cartilage when using 80 mg/cc fibrinogen and 4 x 10(7) chondrocyte/cc at 8 weeks in vitro culture. 4. The compressive modulus is higher in constructs with higher fibrinogen concentration and is 35.4 -36.8% of the normal joint cartilage. 5. The yield stress is higher in constructs with higher fibrinogen concentration and is 11% of the normal joint cartilage. This study demonstrates that fibrin glue is a suitable polymer for generation of cartilage by in vitro culture method. The construct with 80 mg/cc fibrinogen and 4 x 10(7) chondrocyte/cc yields the best quality of cartilage at 8 weeks when analyzed by weight and volume changes, histology and biomechanical properties. The compressive modulus and yield stress of the generated cartilage are lower than those of normal joint cartilage, and may still be adequate for the purpose of craniofacial reconstruction which seeks more pliant cartilage not requiring weight bearing strength.

An Observation of the Change of Clinical Status and Treatment on 134 Cases of Hypospadias During Last 20 Years / 대한비뇨기과학회지

An observation about the age of first visit, the location of external meats and the method and success rate of the first and second operation, was made on 134 hypospadias of the in-patients in the Department of Urology, Yonsei University Hospital during the period of January l966 through July 1985 and the following results were obtained: l. The distribution of the distal shaft type was increased and the penoscrotal type was decreased. 2. In first stage operation, the Byars method was used largely before the period 1980, the Nesbit (67.5%) was used largely after the period l98l. 3. The method of urethroplasty was mainly Thiersch Duplay and Crawford. After the period 1981, Flip-fiap and MAGPI method was also used and the use of microscope (35.7%) was increased. 4. The success rate of Duplay method was increased and of Crawford method was not changed. The total success rate was 72.7% before the period 1975, 55.3% before the period 1980, 71.4% after the period 1981. Especially, the success, rate of operation using microscope was 80%. 5. The success rate according to meatal location was increased when the meatus was more distally located.

A Case of Impotence due to Pituitary Adenoma / 대한비뇨기과학회지

The endocrine cause of impotence is about 10-15% of all impotence. If hyperprolactinemia is noted, the pituitary adenoma should be suspected. Usually, the early symptom of pituitary adenoma is impotence and other symptoms of CNS appear later. So impotence is a very important clinical symptom not to be neglected. It had taken 8 years to diagnose the pituitary adenoma, whose early symptom was impotence. He received operation and radiotherapy and has been taking care of his sustaining hyperprolactinemia. When we review his past history. it is not overemphasized that impotence is important to diagnose pituitary adenoma."

A Case of Renovascular Hypertension in Child / 대한비뇨기과학회지

The hypertension in children is relatively rare disease and renal arterial disease does constitute a relatively more common cause of hypertension in children. Recently, we experienced a case of renovascular hypertension due to left renal artery stenosis in 11-year-old boy, corrected by splenorenal bypass and good result was obtained. Herein we report a reconstructive vascular procedure with some literatures.